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Primary Work Address: 1550 4th Street, Suite 190, San Francisco, CA, 94158-0724
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We are looking for a Research Specialist II to join the Shokat lab at our University of San Francisco location. Kevan Shokat studies two of the most critical types of regulatory enzymes in the body – kinases and GTPases – both of which are key to directing cell activity. Dr. Shokat develops novel chemical tools to decipher how these enzymes interact with other proteins and contribute to cell signaling networks, under both normal and diseased conditions. A deeper understanding of kinases and GTPases and how they coordinate cell-cell communication may lead to more effective therapeutics for diseases such as cancer, Parkinson’s, and other forms of immune dysfunction. For more information about the lab visit, https://www.hhmi.org/scientists/kevan-m-shokat
About the role:We are seeking a highly skilled and motivated Scientist with expertise in Cheminformatic & Computational Chemistry. The successful candidate will join our team and contribute to various research projects in small molecule drug discovery using machine learning algorithms. They will be responsible for developing and implementing QSAR/QSPR models, providing bioinformatics support, and contributing to computational chemistry projects. The Scientist will also support our laboratory information management system. This is an exciting opportunity to work in a dynamic and innovative environment, leveraging cutting-edge technologies to drive drug discovery efforts.What we provide:A competitive compensation package, with comprehensive health and welfare benefits.A team that believes in continuous learning and cultivates an environment of collaboration.Opportunity to work in a diverse and motivating research environment.Multiple opportunities to present your research.Weekly meetings with Dr. Shokat and lab members in a collaborative and highly team-oriented setting.Successful projects in which the candidate participates may lead to authorship on scientific publications.What you’ll do:Perform various specialized scientific investigative procedures in support of assigned research projects.Computational chemistry project support using modeling software such as Schrodinger and MOE tools.Should have experience in Boron based oxygen electrophilic compounds including AI/ML models for predicting their properties such as metabolic liabilities and association with protein bound nucleosides.Conduct literature reviews to be used in determining the most suitable research methods. Identify methodological problems in research protocol and implement modifications to optimize experimental results.Review available technology and assist in bringing appropriate new technology into the laboratory.Prepare reports about research projects for presentation at scientific meetings. With guidance, prepare manuscripts for publication.Use software applications to assemble, manipulate, format and/or perform statistical analyses of complex data.Routinely review research activities to determine where new information could improve processes or move projects forward.Review operational needs, develop, and implement intermediate and long-term goals. May prepare specifications for equipment and supplies needed in support of research for scientific studies.May configure, operate, and/or maintain specialized equipment; may train others in the use of equipment.What you bring:Master of Science degree, preferable PhD in Chemical Sciences or an equivalent combination of education and related work experience.One year of experience as a Research Specialist I or equivalent (Five years of related work experience).Technical proficiency, scientific creativity, collaborative ability as well as independent thought.In-depth knowledge of multiple areas and of the underlying principles and concepts. Frequently addressed by colleagues within their institution to obtain specialized information.Ability to work inclusively and collaboratively with diverse population.Ability to monitor the performance of others and identify areas where additional training can further research goals.Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.Ability to write and prepare reports or manuscripts for presentation to large audiences.Physical RequirementsRemaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.Please Note:This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.Compensation Range$77,740.00 (minimum) – $97,200.00 (midpoint) – $126,385.00 (maximum)Pay Type:AnnualHHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate’s education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.HHMI is an Equal Opportunity Employer
