Lexicon Pharmaceuticals Hiring For Associate Director, Computational Biology and Data Sciences at Basking Ridge, NJ  Full Time

Tracking Code

590-252

Job Description

The Associate Director of Computational Biology and Data Sciences will support the Executive Director, Scientific Evaluation and Strategy, in identifying and evaluating potential opportunities arising from our proprietary Lexicon Gene Targeted KO discovery platform. The focus will be on identifying and prioritizing unique targets to add to our drug dicovery portfolio for internal development or for external partnering. The successful candidate profile is an entreprenurial scientist with experience working in a matrix environment and getting results through influence. He/She will develop and implement a strategic vision for leveraging computational biology for target discovery, understanding mechanism of action of targets, and designing prognostic, predictive, and pharmacodynamic biomarkers. Additionally, he/she will bring deep scientific experience with large data set processing and visualization for the understanding of target and disease biology.

This role can be based out of our Basking Ridge, New Jersey or The Woodlands, Texas location or can be done remotely.

Key Responsibilities include but will not be limited to:

• Data mining of Lexicon’s proprietary database of ~5000 Gene Knock Outs and phenotypic data, and internal drug discovery databases and materials.
• Thorough analysis of the scientific literature and systems biology databases for human gene correlates to drug targets and disease indications. (e.g. GWAS, protein and RNA expression databases)
• Design and coordination with CROs for functional genomics scientific support of target validation and mechanism of action pathways.
• Review of patents, publications etc. to determine the competitive environment of potential Drug Discovery programs.
• Provide input into Drug Discovery strategy
• Attend and present at internal meetings, including Executive Management and Research Leadership Team and external meetings as needed.

Required Experience

Qualifications:

• PhD in bioinformatics, data science, or related discipline required
• A minimum of 5 years applying bioinformatics in a drug discovery or academic environment.
• Experience in biological pathways, data visualization, network and systems biology (IPA, KEGG, GSEA, GeneGO, Cytoscape, Reactome).
• Proficiency using R and Bioconductor packages and one or more programming language (Python, Perl, and Javascript).
• Experience working with Linux environment, high-performance computing clusters, and cloud computing.
• Outstanding verbal and written communication skills as well as strong presentation skills
• Ability and desire to work in a team-oriented environment
• Ability to lead through influence

• Direct experience of using bioinformatics to evaluate and prioritize new drug discovery targets and programs.

To apply, please visit the careers section of our website: .

For additional information about Lexicon and its programs, please visit .

Lexicon is an Equal Opportunity Employer. We do not discriminate based on race, color, religion, sex, sexual orientation, gender identity, national origin, disability or status as a protected veteran.

Lexicon Pharmaceuticals, Inc. is a drug-free workplace. Candidates are required to pass a drug test, background check and verification of credentials before beginning employment.

Job Location

Basking Ridge, New Jersey, United States

Position Type

Full-Time/Regular

Lexicon Pharmaceuticals, Inc. is an equal opportunity/affirmative action employer.