Nuprobe USA Inc Hiring for Verification and Validation Scientist Job at Houston, TX Full Time

NuProbe USA is hiring a V&V Scientist for its Houston (TX) location. NuProbe USA is a startup devoted to the development of affordable, accurate, and non-invasive DNA diagnostic assays for cancer and other diseases. The successful candidate will contribute to the development of Next Generation Sequencing (NGS) panels for detecting rare oncogenic mutations. Work is focused on the development of verification and validation (V&V) activities for multiple systems comprised of assays, reagents, consumables, instruments, and software. The role requires a strong leadership and detail-focused skillset to design, plan, and execute tests of products exiting development and to further support and improve products.

Essential Job Duties and Responsibilities:

Essential responsibilities and duties include, but are not limited to the following:

· Act as the Technical lead on studies in support of the integration, verification, and validation of automated NGS assays used in clinical laboratory products in a regulated environment

· Collaborate closely with other assay, automation, software, and operations team members to integrate and functionalize novel complex automated assays

· Drive development efforts to optimize assay performance, improve laboratory processes, and ensure production robustness

· Conduct troubleshooting investigations and related experimentation to address acute or systematic issues with implemented systems

· Collaborate closely with biostatistics and bioinformatics functions to develop robust study designs and comprehensive analyses

· Work with Quality and Regulatory team members to ensure studies fulfill necessary guidelines and regulations (CAP/CLIA/FDA)

· Develop experimental plans that support PMA study objectives

· Execute laboratory experiments in collaboration with more junior technical staff to generate high quality data by following best practices of assay and instrument operations

· Perform data analysis and document study outcomes and conclusions

· Summarize, present and document study outcomes to key stakeholders

· Support training of junior Research Associates

Job Qualifications and Education:

· PhD degree in Molecular Biology, Genetics, Cancer Genomics, or relevant fields with 3+ years of postdoctoral or industry experience.

· Strong hands-on laboratory experience and in-depth knowledge of Illumina NGS workflows including nucleic acid extraction, library preparation, target enrichment, and sequencing.

· Hands-on experience with automated laboratory instrumentation such as liquid handlers.

· Experience with the development, optimization, and troubleshooting of NGS assay protocols on automated systems.

· Experience with the development and implementation of clinical laboratory tests regulated environments is a plus.

· Experience with design control and change control.

· Experience with standard nucleic acid analytical techniques (e.g, qPCR, Nanodrop, Fragment Analyzer, ddPCR).

· Experience with statistical programming or software.

· Experience with Design of Experiment (DOE) a plus.

· Attention to detail, safety, good laboratory practice, and good documentation practice.

· Strong verbal and written communication skills and willingness to collaborate cross-functionally in a fast-paced and dynamic environment.

Benefits:

· Company benefits, (medical, dental, vision, unlimited PTO, 401k and more)

· Professional growth: We believe in people, and we foster professional growth.

· Starting compensation will be based on experience.

Visa Sponsorship:

NuProbe is willing to sponsor H1-b work visa for the successful candidate

This job description describes the major responsibilities of the job. It does not include all aspects of the position, such as the potential additional duties assigned by management, and the requirement for flexibility in assisting others for the company’s overall benefit.

About NuProbe USA:

NuProbe USA is the US-based R&D subsidiary of NuProbe Global, a company that recently raised $62M YTD to develop novel non-invasive DNA. Its technology enables precise and comprehensive capturing of disease signatures with uniquely high sensitivity and multiplexing capability. NuProbe technologies can reduce the cost of NGS by 50-fold and improve the sensitivity of qPCR, Sanger, and nanopore sequencing by over 100-fold. NuProbe’s technologies and products are globally recognized, and NuProbe has multiple partnerships with leading sequencing companies such as Illumina, Oxford Nanopore, and QIAGEN, and hospitals such as MD Anderson, Baylor College of Medicine, and Yale School of Medicine. As a global company, NuProbe also has a China site based in Shanghai and cGMP facility in Suzhou. NuProbe is co-founded by Prof. Peng Yin at Harvard University, David Zhang (former professor at Rice University), and Dr. Victor Shi (former founding president of Qiagen Asia.

Job Type: Full-time

Pay: $105,000.00 – $130,000.00 per year

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Flexible spending account
• Health insurance
• Health savings account
• Life insurance
• Paid time off
• Relocation assistance
• Vision insurance

Schedule:

• 8 hour shift
• Monday to Friday

Supplemental Pay:

• Bonus pay

Ability to commute/relocate:

• Houston, TX 77054: Reliably commute or willing to relocate with an employer-provided relocation package (Required)

Education:

• Doctorate (Required)

Work Location: One location