Novartis Hiring for Research Scientist, Neuromuscular Diseases – Gene Therapies (BS or MS) Job at Cambridge, MA Full Time

1. Thats the number of current viral gene therapy treatments approved by the FDA and EMA for any neuromuscular disease. Novartis’ AAV gene therapy approved for the treatment of spinal muscular atrophy offers patients a transformative option in their fight with this devastating disease. Novartis Institutes for Biomedical Research and the Musculoskeletal disease area are committed to development of the next generation of life saving medicines for the world’s most severe medical disorders.

The Musculoskeletal group in Cambridge is seeking a highly motivated BS/MS level scientist to join our early stage drug discovery department. Our group is developing gene therapies for neuromuscular diseases, exploring disease mechanisms and potential treatments including target identification, validation and subsequent developing therapeutic interventions. In the role, you will be working on gene therapy and conventional drug discovery projects. Your role involves developing in vitro and ex vivo functional and phenotypical assay systems as well as exploration of novel biomarkers and readouts in disease models using new technologies. You will be part of an interdisciplinary, highly collaborative group.

The successful candidate will be responsible for:

Performing molecular, cellular biology and pharmacology techniques to support proprietary gene therapy platform technologies for the creation of new therapeutic candidates.

Applying a diversity of in vitro techniques to identify and validate assays and characterize cellular models of disease.

Applying a diversity of ex vivo/in vivo techniques to assess preclinical samples for pharmacodynamic biomarkers and innovative readouts.

Generating, analyzing, and documenting study results, as well as interpreting and presenting data to multidisciplinary groups

Keeping current on emergent technologies through literature review and scientific meetings

What you’ll bring to the role:

MS, BS or equivalent degrees in the life sciences with 4+ years of proven ability, preferably in industry.

Expertise with in vitro methods including, but not limited to molecular and cellular biology. Viral vector techniques are desirable.

Expertise in ex vivo/in vivo methods including biomarker and tissue analysis would be helpful

Knowledge and hands-on experience in designing and implementing assays (e.g. cell culture, qPCR, IHC/IF, ELISA, gene and protein analysis, imaging).

Ability to document, organize, communicate, and present sophisticated data sets to multidisciplinary groups.

Ability to multi-task, work collaboratively as well as independently, be scientifically curious and self-motivated

Excellent oral and communication skills, analytical skills, and interpersonal skills

Why consider Novartis?

769 million. That’s how many lives our products touched in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

Here, where we value your ideas, personal growth and career aspirations; you will be surrounded by and learn from curious, unbossed colleagues across multiple disciplines; you will be empowered to take smart risks, and to use your creativity and tenacity to work towards creating the next pharmaceutical.

We are Novartis. Join us and help us reimagine medicine.

Imagine what you could do at Novartis!

Commitment to diversity & inclusion:

Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.